Andre Rosowsky Selected Research

Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)

3/2009	Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes.
9/2008	Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine.
5/2004	Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.
5/2003	Further studies on the interaction of nonpolyglutamatable aminopterin analogs with dihydrofolate reductase and the reduced folate carrier as determinants of in vitro antitumor activity.
4/2003	Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.
1/2003	Synthesis of new 2,4-Diaminopyrido[2,3-d]pyrimidine and 2,4-Diaminopyrrolo[2,3-d]pyrimidine inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.
1/2002	Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.

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Andre Rosowsky Research Topics

Disease

6	Acquired Immunodeficiency Syndrome (AIDS) 03/2009 - 01/2003
3	Leukemia 12/2004 - 01/2002
1	Pneumonia (Pneumonitis) 03/2009
1	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 09/2008
1	Malaria 11/2007
1	HIV Infections (HIV Infection) 04/2003
1	Neoplasms (Cancer) 06/2002

Drug/Important Bio-Agent (IBA)

7	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 03/2009 - 01/2002
4	Folic Acid AntagonistsIBA 11/2007 - 01/2002
2	EnzymesIBA 03/2009 - 04/2003
2	Reduced Folate Carrier ProteinIBA 12/2004 - 05/2003
2	piritreximIBA 05/2004 - 04/2003
2	Thymidine Monophosphate (TMP)IBA 05/2004 - 04/2003
2	Trimethoprim (Proloprim)FDA LinkGeneric 05/2004 - 04/2003
2	N(alpha)- (4- amino- 4- deoxypteroyl)- N(delta)- hemiphthaloyl- L- ornithine (PT 523)IBA 05/2003 - 01/2002
1	AzepinesIBA 05/2004
1	Oxidoreductases (Dehydrogenase)IBA 04/2003
1	dihydrofolateIBA 04/2003
1	ThiophenesIBA 06/2002
1	Glutamic Acid (Glutamate)FDA Link 06/2002
1	AcidsIBA 06/2002
1	lometrexolIBA 01/2002
1	Methotrexate (Mexate)FDA LinkGeneric 01/2002
1	Pemetrexed (MTA)FDA Link 01/2002
1	ZD 9331IBA 01/2002
1	Thymidylate SynthaseIBA 01/2002
1	raltitrexed (D 1694)IBA 01/2002
1	Phosphoribosylglycinamide FormyltransferaseIBA 01/2002
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2002

Therapy/Procedure

2	Drug Therapy (Chemotherapy) 03/2004 - 04/2003